H2N2V1, Main, Exploration, bibRecord, 002308

Comparison of the amino acid sequences of the major neutralization protein of four human rotavirus serotypes

Identifieur interne : 002308 ( Main/Exploration ); précédent : 002307; suivant : 002309

Comparison of the amino acid sequences of the major neutralization protein of four human rotavirus serotypes

Auteurs : Kim Y. Green [États-Unis] ; Karen Midthun [États-Unis] ; Mario Gorziglia [États-Unis] ; Yasutaka Hoshino [États-Unis] ; Albert Z. Kapikian [États-Unis] ; Robert M. Chanock [États-Unis] ; Jorge Flores [États-Unis]

Source :

Virology [ 0042-6822 ] ; 1987.

RBID : ISTEX:104B8BC4AF432A7D64B2DF77FDCA9B79D38A3ECB

English descriptors

Teeft :
- Amino, Amino acid sequence, Amino acid sequences, Amino acids, Animal rotaviruses, Antigenic, Chanock, Different serotypes, Divergent regions, Gene encoding, Glycoprotein, Homology, Human rotavirus, Human rotavirus serotypes, Human rotavirus strains, Human rotaviruses, Human strain, Kalica, Kapikian, Monoclonal antibodies, Ncdv, Neutralization, Neutralizing, Nucleotide sequence, Rotavirus, Rotavirus serotypes, Same serotype, Sequence divergence, Sequencing, Serotype, Serotypes, Simian, Substitution, Viral, Wyatt.

Abstract

Abstract: We sequenced the gene coding for the major neutralizing protein (VP7) from eight human rotavirus strains representing serotype 1, 2, 3, or 4. In addition, the corresponding gene of the rhesus rotavirus vaccine strain MMU18006 (serotype 3) was sequenced. Comparative analyses of their deduced amino acid sequences revealed an overall 15–29% divergence in the VP7 proteins that define four different rotavirus serotypes and confirmed the presence of six discrete regions of clustered sequence divergence (amino acids 39–50, 87–101, 120–130, 143–152, 208–221, and 233–242). When the same regions were compared among rotaviruses belonging to the same serotype, a high degree of homology (91–99%) was detected. These observations indicate that differences in the serotype specificity among rotaviruses are the result of a high degree of sequence divergence in several discrete regions of the VP7 gene and that these regions are highly conserved within a given serotype.

Url:

https://api.istex.fr/ark:/67375/6H6-P37S89MJ-6/fulltext.pdf

DOI: 10.1016/0042-6822(87)90181-4

Affiliations:

États-Unis

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Le document en format XML

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<front><div type="abstract" xml:lang="en">Abstract: We sequenced the gene coding for the major neutralizing protein (VP7) from eight human rotavirus strains representing serotype 1, 2, 3, or 4. In addition, the corresponding gene of the rhesus rotavirus vaccine strain MMU18006 (serotype 3) was sequenced. Comparative analyses of their deduced amino acid sequences revealed an overall 15–29% divergence in the VP7 proteins that define four different rotavirus serotypes and confirmed the presence of six discrete regions of clustered sequence divergence (amino acids 39–50, 87–101, 120–130, 143–152, 208–221, and 233–242). When the same regions were compared among rotaviruses belonging to the same serotype, a high degree of homology (91–99%) was detected. These observations indicate that differences in the serotype specificity among rotaviruses are the result of a high degree of sequence divergence in several discrete regions of the VP7 gene and that these regions are highly conserved within a given serotype.</div>
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Comparison of the amino acid sequences of the major neutralization protein of four human rotavirus serotypes

Comparison of the amino acid sequences of the major neutralization protein of four human rotavirus serotypes

Source :

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri